Mikhail Blagosklonny’s Journeys with Anti-aging Drug Paying Returns

Posted on

Mikhail Blagosklonny, a renowned scientist in cancer and aging, and his contributions in anti-aging drugs are paying greater returns in the recent years. The hyperfunction theory put forward by Blagosklonny in the 2000s became the basis of all the anti-aging research in the later years. Though it was ridiculed by other researchers in the initial years, now it is proving to be a significant milestone in the development of treating age related health problems. With hyperfunction theory, Blagosklonny explained that aging should be considered as the continuation of growth that is driven by some types of signaling pathways like TOR or Target of Rapamycin. Until then, it was believed that aging was a functional decline caused by random molecular damages – something that cannot be prevented.The TOR model predicted that rapamycin and other rapalogs could be used to prevent diseases and treat aging. It says that by using proper dosages and schedules, people can extend their healthy lifespan. Though it was ridiculed by many peer reviewers, it also predicted that five years from then, people would take it as granted. The current development shows that the prediction was accurate and fulfilled. Currently, Evirolimus – a rapamycin analog – ensures immunity in aging people and led to further research in anti-aging drugs. It should be noted that Novartis started working on “Youth Drug” that can delay the various effects of aging and provide better health for older adults. Altogether, the drug targets everything related to aging and ensures a comfortable and healthy condition in the later part of the life.

In 2006, rapamycin was approved as a drug to use for cancer, autoimmunity, metabolic disorders, cardiovascular diseases, age related diseases from osteoporosis to Alzheimer’s, and more. Interestingly, it is safe for daily use for several years and can rejuvenate immunity. By 2010, most of the predictions of the TOR-centric model was found to true. It should be noted that the theory put forward by Blagosklonny also predicts calorie-restriction-mimicking technic of rapalogs and its side effects. It is found that rapamycin can create starvation-like symptoms in some conditions. The induced state caused by rapamycin stops the complications of type II diabetes. The mTOR-centric model suggests the reversible insulin resistance by rapamycin can increase the longevity of humans as it can lead to decreased mTOR pathway signaling.

Mikhail Blagosklonny works with Roswell Park Cancer Institute as a professor of Oncology. He is associated with a number of journals and works as the editor-in-chief of Cell Cycle and Oncotarget. Blagosklonny is also the associate editor of the American Journal of Pathology, PLOS ONE, International Journal of Cancer, and Cancer Biology and Therapy. Apart from aging and cancer, he also researches from clinical investigations to cellular and molecular biology. Blagosklonny wrote more than 300 reviews, research articles, book chapters, and more. Mikhail earned his MD in Internal Medicine from the First Pavlov State Medical University, St. Petersburg. He continued there and earned a Ph.D. in Cardiology and Experimental Medicine. Blagosklonny started his career with New York Medical College as an associate professor of medicine. Later, he joined Ordway Research Institute as a senior scientist, before joining Roswell Park.You can also follow them on Twitter : https://twitter.com/oncotargetjrnl?lang=en

Dr. AviWeisfogel Brings a Very Unfavorable Concern with Respect to Sleep Disorder to the Forefront:

Posted on

Dr. AviWeisfogel has spent a good deal of his life accumulating information and responding, accordingly, in order to address a serious on-going condition with respect to a sleeping disorder. The disorder is that of sleep apnea.

So what happens when an apnea occurs, during a person’s nighttime sleep process? The person, undiagnosed, will experience a halt as to breathing. This is something, according to Dr. Weisfogel, as well as other professionals, within the healthcare community, which one should not take lightly. The ceasing of breath, without the sufferer’s knowledge, causes a great deal of health concerns, during daytime hours.

A person, experiencing night apneas, may feel groggy and fall asleep, during the day. He or she may become accident prone. The apnea patient, if going untreated, may develop changes in mood. His or her cognitive ability–as far as concentration is put to the test.
The disorder of sleep apnea, too, has been linked to serious diseases such as cardiovascular abnormalities diabetes. What is the solution?

Dr. AviWeisfogel has found solution, in way of his Dental Sleep Masters’ program. The program is reliable and presents the Dental Practitioner and Physician, with a positive approach, in remedy of the situation.

The airway, is kept open, by way of a user-friendly oral appliance. By using the remedy, the client retention rate, remains high: as high as 90 percent. The preceding fact is quite, encouraging, for the physician and for the Dental practitioner.

Upon reading the reviews, one Physician mentions that he is very motivated that his “numbers” are increasing, in way of seeing patients, that require help. He uses the popular Dental Sleep Masters’ Program within his practice. He is very busy, and he finds, the fact, that persons are properly, identified, as to having the disorder and are given the proper plan of treatment extremely encouraging.

Dr. AviWeisfogel–himself–began his career as a Dental Practitioner within the Township of Old Bridge New Jersey–a delightfus area of the United States. This idyllic “All American” community is where Dr. AviWeisfogel began his successful journey into the realm of sleep. He became interested, actually, while practicing Dentistry in “Old Bridge, in the area of sleep to learn more: http://thebrotalk.com/sports/avi-weisfogels-controversial-outlook-on-the-2017-2018-knicks/ click here.

After fifteen years of practicing Dentistry, in Old Bridge, he began working with Physicians and Dentists, in order to show them how to implement a sleep lab and remedy, into their existing practices. He provided instructions, by way of Webinars; and conducted in-person seminars.

He, eventually, arrived at the point he is today: establishing Dental Sleep Masters Program. The program shows Dental Practitioners; and Physicians how to incorporate a sleep component into an existing practice. At the same time, it provides the healthcare professional, information, about how to properly identify patients, who possess the insidious disorder.

Everybody wins as a result of Dr. AviWeisfogel’s Dental Sleep Masters Program. The healthcare provider, wins, due to the fact he or she can actively identify patients with sleep apneas; and work with these patients, in order to provide an apt and proper remedy. She or he, too, is provided with a second income stream.

The patient, wins, since he is directed how to take care of a perilous health concern and, to do so in a way, that is not threatening or scary.

The general public, wins, due to the fact they are provided with necessary information and a resource, in way of addressing Sleep Apnea, a condition that goes highly undiagnosed.

Notes Regarding Dr. AviWeisfogel:

It is correct to note that Dr. AviWeisfogel, over the years, has accumulated a great deal of knowledge, as it pertains to sleep disorders. He attained his academic standing, by acquiring B.A. Degrees in Biology and Psychology from Rutgers Universtiy. Dr. AviWeisfogel attained a D.D.S. from the New York University College of Dentistry.

He is an avid sports spectator. He spends his time off with his family and puppy. He additionally enjoys the sport of skiing.

Get To Know Oncologist Mikhail Blagosklonny

Posted on

Oncology is simply defined as the study and treatment of tumors. Dr. Mikhail Blagosklonny is scientist expanding oncology with his focus on groundbreaking concepts. He is currently on staff at Roswell Park Cancer Institue as a professor of Oncology. Mr. Blagosklonny studies every aspect of aging and cancer.He earned his MD in Internal Medicine and his Ph. D. in experimental Medicine and Cardiology while attending the First Pavlov State Medical University of St. Petersburg. In 2002 he was the associate professor of medicine at New York Medical College in Valhalla, New York.He was the senior scientist at Ordway Research Institue. In 2009 he became a member of the staff at Roswell Park Cancer Institute as the Professor of Oncology.

His Research Topics Of Interests Include:

*Biogerontology (underlying mechanisms of aging)

*Anti-Aging Drugs


*Targeted Cancer Therapies

Get To Know Oncologist Mikhail Blagosklonny , not only is Mr. Blagosklonny the associate editor of cancer biology and therapy, he also works for both Oncotarget and Cell Cycle as the editor-in-chief. He is also a member of the editorial board of Cell Death and Differentiation. Mr. Blagosklonny is credited with the hypothesis regarding Target OfRapamycin (TOR) Signaling cancer and aging.He offered that Rapamycin could be utilized as a means for life management and treatment. Rapamycin is very well known for its use in the fight against cancer.Known for his zeal as an advocate for Rapamycin, Mr. Blagosklonny’s research varies from a wide array of topics such as:

*Cellular Biology

*Molecular Biology

*Clinical Investigations

The Main Focus Of Mikhail Blagosklonny’s research includes among other things:

*Signal Transduction


*Tumor Suppressors

*Drug Resistance For Normal Cells Selective Protection


*Cell Cycle

*Anti-Cancer Therapeutics


The Author Mikhail Blagosklonny Has Accomplished:

*Over 300 published research articles, book content, and reviews.

*Author of aging hyperfunction theory

*Author of articles about cell Cyclotherapy and chemotherapeutic engineering

*Associate editor for PLOS ONE, the American Journal of Pathology, and International Journal of Cancer.

He has a blog@: https://www.dovepress.com/oncotargets-and-therapy-journal where you can get to know Mikhail and hyperlink to a new window at google scholar where you can check out his articles.

The Top 5 List Of Articles From Mikhail Blagosklonny:

  1. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
  2. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
  3. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
  4. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
  5. Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

Mikhail is known for loving his job as an oncologist and for sincerely believing in the human ability to not only control cancer but to eradicate it with the use of Rapamycin. He feels that controlling aging is possible as well. When asked what motivated him into his field of work he responded that it was his love for humanity and his vision of seeing a disease-free community that did it.


Posted on

Anthony Petrello who is fondly referred to as “Tony” by those who know him is the Chief Executive Officer of Nabors Industries Limited which is the holding company of Nabors Exchangeco Canada (Inc). He has held the position of Chief Executive Officer since 28th October 2011. Anthony Petrello has also served in various other capacities in Nabors Industries Limited as President, the Chairman of the Board, the Vice Chairman of the Board and as the Chief Operating Officer. His contribution has been invaluable at Nabors Industries Limited. He has over the years become indispensable to the company.

Prior to his career as Nabors Industries Limited, he was the Managing Partner at a law firm called Baker and McKenzie from 1986 to 1991 in its New York City Office. As the Managing Partner at the law firm, he had both managerial roles and business roles to play a role that he executed very well. Other capacities in which Mr. Anthony Petrello serves are: Director of Stewart and Stevenson, LLC since 28th February 2011 and Director of Texas Children’s Hospital.

With regards to his academic qualifications, Mr. Anthony Petrello holds a J.D Degree from Harvard University and M.S and B.S Degrees in Mathematics from the Yale University. He has always been exceptional academically.He excels at everything that he puts his mind on or every task that he takes on. He has been described as a self-driven and innovative person.

Anthony Petrello is not only a successful professional but he is also a humanitarian. His daughter Carena ails from a neurological illness called Periventricular Leukomalacia which has impeded her growth. Anthony and his wife Cynthia turned their tragedy into an avenue to do good. They are actively involved in the activities of Texas Children Hospital so as to ensure that research is conducted into such neurological conditions so as to get more information.



Honey Birdette Takes on Europe and The US

Posted on

Honey Birdette, Australia’s first sensuality boutique, announced a huge rollout of stores in the United Kingdom, expecting to total 40 retail locations by the end of 2018. This announcement comes on the heels of their first three UK locations, all which were a smash success and left people in the UK asking for more locations. The first three locations were in London, Newcastle and Leeds.

Honey Birdgette is becoming a major player in the world of high end lingerie, accessories and toys. It is creeping up on some of the biggest names in the business due to its innovative approach. The store combines high end lingerie and toys with a lavish atmosphere of ornamental lighting, champagne for all guests and best of all: access to the experts, the Honeys. The team of Honeys at each locations put on what can be called something close to a show as they entertain guests, share their wide amount of knowledge and make suggestions to allow customers to venture outside of their comfort zone.

Honey Birdette was founded by Eloise Monaghan in 2006 after a cocktail conversation between friends revealed that many of them were looking but unable to find access to higher end lingerie in a classy environment in Australia. After the idea was sparked, Monaghan put her entrepreneurial mindset to work and lunached Honey Birdette. She still works as the Creative Director and hand selects every item shown in her stores.

The growth of the retail presence was announce along with a new digital focus for Honey Birdette: a website that caters to the e-commerce needs of customers in the United States. After seeing a 12 month increase in US sales that amounted to 370% in growth, the new website was created to meet the rising demand. This site will treat US customers to faster shipping, a more extensive product line and easier return.

Cancer Treatment Centres of America

Posted on

The Cancer Treatment Centers of America consist of five hospitals located in Atlanta, Chicago, Philadelphia, Tulsa and Phoenix. Its headquarters is located in Boca Raton, Florida. They not only offer treatment for cancer patients through chemotherapy, surgery, immunotherapy and radiation, but also provide care and therapies such as for the depressed, pain and lymphedema. Stephenson, whose mother had died from cancer, started the first cancer treatment center because it inspired him to helping other people suffering from this disease.
At these centers, they determine the type of cancer and the level at which it has reached before beginning the treatment process. They treat several cancers including breast cancer, prostate cancer, ovarian cancer, lung cancer and pancreatic cancer. In addition, these centers consists of well-trained certified doctors, who are caring and ready to treat patients using insurance or cash payment. Moreover, they have modern medical equipment, which helps with the diagnosis and treatment of the patients and are certified to indulge in medical research trials on willing patients.
According to the article, the cancer treatment center of America joined forces with NantHeath and Allscripts to launch an advance medical system. NantHealth is known for its technology, which analyzes the state of the cancer in real time and prescribes the right medication. On the other hand, Allscripts collects all the data on patients and connects different people and places that help the physicians in decision making so that they are able to relate some symptoms and come up with a fast option of treatment.
In conclusion, the coming together of these health centers to form Clinical Pathways ensures that patients receive maximum treatment quickly and therefore reducing chances of misdiagnosis and mistreatment. It also means that many oncologists can access the data quickly anywhere for research and study thus improving on advancing cancer treatment.

Better teachers create smarter students

Posted on

We all know very well that parents are a child’s first teacher. Once that child is school age many parents think their job is done, that is very far from the truth. At such an early age the human brain absorbs information much like a sponge absorbs water. Teachers can only do so much in the time allowed during the school year so they depend on the parents to reinforce what their child has learned. With the development of ClassDojo parents, teachers and students can all stay in contact with each other. Comparable to social media you can share media photos, videos, and messages all in one place. Why wonder what your child learned in school today when you can see it for yourself? Nervous first-day jitters, don’t worry mom because your teacher can send you a message with a high five letting you know he or she is doing fine! ClassDojo really gives kids a voice of their own and allows them to express an interactive role in their learning experience. As parents, we get to see how our children are progressing throughout the year. An example is a homework assignment that your child is saying that she turned in but the grade hasn’t gone up. You have access to log into the app and check homework assignments and so much more. Writing assignments are a huge eye opener because you can really tell if your child is picking up on what is being taught. Questions or concerns about your child’s learning development or behavior can be addressed right through the app. personally if one was to ask why this app I would have to respond back, why not?

Tips On Working With NuoDB Cloud-Based Technologies

Posted on

This blog is on tips for making it work with NuoDB cloud-based Service providers. When you play host with a NuoDB cloud based service provider it becomes a two-way street. You have to make it work for you and your team. Seeing as how you are the customer, it has to work for your interests. Those NuoDB cloud database providers who do not keep this in mind, the enterprises will be less than successful.

Here are 3 ways to help you out.

1) Say that you want to spend $100,000 a year or more on the NuoDB cloud. Your provider has to be sure this is a realistic goal. The profit margins have to line up or it is not going to work, no matter what the number is.

“You have to have a goal, as well as a means to an end”.

2) Check out the history of the NuoDB provider you are looking into. The history should be a good one, otherwise, it is not worth taking a chance.

3) The level of support you get from your NuoDB service provider needs to be sufficient enough for you. Their support needs to work in your favor, not theirs. Anything less is a waste of time.

Cassio Audi’s Musical Path with the ‘Viper’

Posted on

Cassio Audi’s Musical Path with the ‘Viper’
Much if not a lot is known about Cassio Audi’s illustrious career as a financial analyst but not his early music career, as it has remained a bit in the dark. His early music career springs for the 80’s when he used to follow the British heavy metal music and could sing along to their tunes to the amusement of his fellow teenagers. It was until 1985 when joined a music band and became its active member. The group was referred to as the ‘Viper ‘rock band.

Specialty in Rock and Pop
With the band having specialized in rock and pop songs, they got accolades from new fans in the country that were enjoying this new genre of music. And with the help of Cassio, the band was able to compose a lot of songs that culminated in their first mega project in 1987 which was an album. The album named Killer Sword was an only a masterpiece as it represented the growth that the band had experienced over the two years that it was formed. The progress after this was simply amazing as Cassio managed to find a blend of metal and classical music, which later turned out to be the neoclassical style of songs.
Soldiers of Sunrise Album
The follow-up of this new style gave rise to the second album called the Soldiers of Sunrise. It is through this album that Cassio and his band members got major shows outside Brazil. They staged performances as far as Europe and they managed to compete favorably with other rock bands from established countries such as the USA and Britain. Cassio’s musical journey just came to an end in 1989 when he finally quit the band to pursue his studies in financial management. But even as he left, he had left a mark in the music industry as a prolific and a talented young man.

Yanni Hufnagel Career Highlights

Posted on

Yanni Hufnagel, a former graduate of Cornell University and Bachelor of Science degree holder, is now serving as assistant coach of the Nevada Wolf Pack men’s basketball team, and has previously coached for notable teams such as the Harvard Crimson. Yanni Hufnagel’s career has led him to making big achievements in getting his very own team ranked nationally, and participating in the NCAA tournament. He has been recognized on CBS Sports in it’s 2012-13 College Basketball Preview. Yanni Hufnagel’s career has led him to coaching multiple men’s basketball teams such as the New Jersey Nets, where he served an internship. Yanni Hufnagel is a former assistant basketball coach of UC Berkeley, along with Vanderbilt University. He also holds experience as a previous Teaching Assistant at the University of Oklahoma. His career skills and focuses that are noted on his professional website at LinkedIn, are public speaking, sports management, athletics, and athletic training. Yanni Hufnagel also has experience with Adult Education, as one of his degrees from the University at Oklahoma is a Master’s in Adult and Higher Education with an emphasis in Intercollegiate Athletics Administration in 2010. The main focus of his career is on basketball and assisting men’s basketball teams. Mr. Hufnagel is a current Managing Partner at IXC.VC since April 2017. He presently works within the Greater New York City Area as seen on LinkedIn. Yanni Hufnagel’s work reflects an amazing and broad career in coaching basketball. Hufnagel is regarded as one of the top recruiters in college basketball.